CAS No.: 4759-48-2
1 Isotretinoin is exact mechanism of action is unknown. Recent research suggests that the drug amplifies production of neutrophil-gelatinase associated lipocalin in the skin, which has been shown to reduce sebum production by inducing apoptosis in sebaceous gland cells while exhibiting an antimicrobial effect on Propionibacterium acnes. The drug decreases the size and sebum output of the sebaceous glands. Isotretinoin combined impact on several of acne's contributory factors distinguishes isotretinoin from alternative remedies such as antibiotics and accounts for its greater efficacy in severe, nodulocystic cases. The effect on sebum production is temporary. However, remission of the disease can be "complete and prolonged. As a chemotherapy agent, isotretinoin may down-regulate the telomerase enzyme, inhibiting "cellular immortalization and tumorigenesis
2 Isotretinoin is a medication used for the treatment of a number of cancers and severe skin conditions. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer, and more. It is still used in the treatment of these cancers because of its ability to kill rapidly dividing cells. We offer best stuff & service, thanks
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